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Although the reactivity of compound was only about 15times higher than that of ebselen under indentical condition, the catalytic mechansium involves the formation of an unusual spiro compound [47]

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Increased oxidation, impaired GSSG reduction, limited NADPH regeneration, reduced synthesis, and preanalytical artifacts can produce similar changes

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Panels D, E, and F show that GSH levels plunge to near zero in all cases, but that GSH recovers more rapidly in females

Moreover, free lipoic acid is rapidly eliminated from cells, so any increases in direct radical scavenging activity are unlikely to be sustained